Asymmetric synthesis and anti-HIV activity of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine

  • Bioorg Med Chem Lett. 1998 Jul 7;8(13):1585-8. doi: 10.1016/s0960-894x(98)00278-9.
P Wang  1 ,  R F Schinazi ,  C K Chu
Affiliations
  • 1. Center for Drug Discovery, University of Georgia College of Pharmacy, Athenes, GA 30602, USA.
PMID: 9873395 DOI: 10.1016/s0960-894x(98)00278-9
Abstract

Asymmetric synthesis of L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine and its analogs were accomplished and their anti-HIV activities were evaluated. It was found that L-carbocyclic 2',3'-didehydro-2',3'-dideoxyadenosine exhibited moderately potent anti-HIV (EC50 = 2.4 microM) activity in human PBM cells without cytotoxicity up to 100 microM.