Rational design of a new series of mixed anti-HIV pronucleotides

  • Bioorg Med Chem Lett. 1998 Nov 3;8(21):3003-6. doi: 10.1016/S0960-894X(98)00535-6.
N Schlienger  1 ,  T Beltran ,  C Périgaud ,  I Lefebvre ,  A Pompon ,  A M Aubertin ,  G Gosselin ,  J L Imbach
Affiliations
  • 1. Laboratoire de Chimie Bioorganique, U.M.R. C.N.R.S. 5625, Université Montpellier II, France.
PMID: 9873664 DOI: 10.1016/S0960-894X(98)00535-6
Abstract

MonoSATE aryl phosphotriesters of AZT are able to deliver intracellularly the corresponding 5'-mononucleotide. This process requires activation by an esterase followed by a phosphodiesterase. This finding opens the way to the design of new pronucleotide series.