2. Membrane Transporter/Ion Channel
  3. Apical Sodium-Dependent Bile Acid Transporter
  4. Ritivixibat

Ritivixibat is an apical sodium-dependent bile acid transporter (ASBT/IBAT) inhibitor. Ritivixibat blocks ASBT/IBAT function, thereby reducing bile acid reabsorption, regulating bile acid homeostasis and alleviating liver injury. Ritivixibat protects cholangiocytes from damage caused by cytotoxic bile acids. Ritivixibat is applicable to research related to primary sclerosing cholangitis.

For research use only. We do not sell to patients.

Ritivixibat

Ritivixibat Chemical Structure

CAS No. : 2460667-52-9

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Ritivixibat Related Antibodies

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Description

Ritivixibat is an apical sodium-dependent bile acid transporter (ASBT/IBAT) inhibitor. Ritivixibat blocks ASBT/IBAT function, thereby reducing bile acid reabsorption, regulating bile acid homeostasis and alleviating liver injury. Ritivixibat protects cholangiocytes from damage caused by cytotoxic bile acids. Ritivixibat is applicable to research related to primary sclerosing cholangitis[1].

In Vitro

Ritivixibat protects rat cholangiocytes from bile acid-induced cytotoxicity in vitro[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ritivixibat Related Antibodies
In Vivo

Ritivixibat improves multiple markers of liver injury in the Mdr2 KO mouse model of primary sclerosing cholangitis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Clinical Trial
Molecular Weight

520.70

Formula

C26H36N2O5S2
CAS No.
SMILES

O=C(CCOC1=C(SC)C=C(N(CC(CCCC)(CCCC)NS2(=O)=O)C3=CC=CC=C3)C2=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ritivixibat Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ritivixibat2460667-52-9Apical Sodium-Dependent Bile Acid TransporterASBTIleal Bile Acid TransporterIBATSLC10A2cholangiocytesapical sodium-dependent bile acid transporterMdr2 KO mouse modelrat cholangiocytesprimary sclerosing cholangitisASBT/IBAThealthy human subjectsInhibitorinhibitorinhibit

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