1. Metabolic Enzyme/Protease
  2. Indoleamine 2,3-Dioxygenase (IDO)
  3. (S)-IDO1-IN-5

(S)-IDO1-IN-5 

Cat. No.: HY-111540B Purity: 99.19% ee.: 99.27%
Handling Instructions

(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1.

For research use only. We do not sell to patients.

(S)-IDO1-IN-5 Chemical Structure

(S)-IDO1-IN-5 Chemical Structure

CAS No. : 2166616-76-6

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10 mM * 1  mL in DMSO USD 157 In-stock
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10 mg USD 300 In-stock
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25 mg USD 500 In-stock
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50 mg USD 800 In-stock
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100 mg USD 1250 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

(S)-IDO1-IN-5 (Example 1B) is an active S-isomer of IDO1-IN-5. (S)-IDO1-IN-5 binds to IDOL with an IC50 value less than 1.5 µΜ[1]. IDO1-IN-5 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[2].

Molecular Weight

396.45

Formula

C₂₃H₂₅FN₂O₃

CAS No.

2166616-76-6

SMILES

O=C(N[[email protected]](C1=CC2=C(N(C(C3CCOCC3)=O)CC2)C=C1)C)C4=CC=C(F)C=C4

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 300 mg/mL (756.72 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5224 mL 12.6119 mL 25.2239 mL
5 mM 0.5045 mL 2.5224 mL 5.0448 mL
10 mM 0.2522 mL 1.2612 mL 2.5224 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 7.5 mg/mL (18.92 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 7.5 mg/mL (18.92 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 7.5 mg/mL (18.92 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

(S)-IDO1-IN-5Indoleamine 2,3-Dioxygenase (IDO)S-isomerLY-3381916IDO1Inhibitorinhibitorinhibit

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(S)-IDO1-IN-5
Cat. No.:
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