2166616-76-6
Chemical Structure
(S)-LY-3381916
Synonym(s): (S)-IDO1-IN-5
- CAS No.: 2166616-76-6
- Formula:C23H25FN2O3
- Molecular Weight:396.45
IUPAC Name: (S)-4-fluoro-N-(1-(1-(tetrahydro-2H-pyran-4-carbonyl)indolin-5-yl)ethyl)benzamide
InChIKey: NUBWFWVVKLRSHS-HNNXBMFYSA-N
SMILES: O=C(N[C@H](C1=CC2=C(N(C(C3CCOCC3)=O)CC2)C=C1)C)C4=CC=C(F)C=C4
Biological Activity: (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ[1]. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1[2].
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(S)-LY-3381916 | 99.06% | (S)-LY-3381916 ((S)-IDO1-IN-5; Example 1B) is an active S-isomer of LY-3381916. (S)-LY-3381916 binds to IDOL with an IC50 value less than 1.5 µΜ. LY-3381916 is a potent, selective and brain penetrated inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity, binds to apo-IDO1 lacking heme rather than mature heme-bound IDO1. | ||||||||||||||||||||
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Keywords
