7758-16-9
Chemical Structure
Sodium pyrophosphate
Synonym(s): Disodium pyrophosphate; Sodium acid pyrophosphate; SAPP
- CAS No.: 7758-16-9
- Formula:Na2H2P2O7
- Molecular Weight:221.94
SMILES: [Na2H2P2O7]
Biological Activity: Sodium pyrophosphate (Disodium pyrophosphate) is an orally active reverse transcriptase ribonuclease H inhibitor. Sodium pyrophosphate forms soluble complexes with iron from ferric pyrophosphate to promote intestinal iron absorption. Sodium pyrophosphate increases the β-sheet content of oxidatively damaged myofibrillar protein gels and enhances the gastric digestibility and antioxidant activity of their digestion products. Sodium pyrophosphate prevents the degradation of RNA-DNA hybrids, inhibits antisense complementary DNA synthesis, induces phage DNA leakage, and causes random mutations in temperate phages[1][2][3][4].
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Sodium pyrophosphate | 98.2% | Sodium pyrophosphate (Disodium pyrophosphate) is an orally active reverse transcriptase ribonuclease H inhibitor. Sodium pyrophosphate forms soluble complexes with iron from ferric pyrophosphate to promote intestinal iron absorption. Sodium pyrophosphate increases the β-sheet content of oxidatively damaged myofibrillar protein gels and enhances the gastric digestibility and antioxidant activity of their digestion products. Sodium pyrophosphate prevents the degradation of RNA-DNA hybrids, inhibits antisense complementary DNA synthesis, induces phage DNA leakage, and causes random mutations in temperate phages. | ||||||||||||||||||||
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- [1]. Cercamondi CI, et al. Sodium pyrophosphate enhances iron bioavailability from bouillon cubes fortified with ferric pyrophosphate. The British journal of nutrition. 2016 Aug;116(3):496-503.
- [2]. Ma W, et al. Role of sodium pyrophosphate and catechin in the enzymatic hydrolysis of oxidatively damaged myofibrillar protein gels in vitro: Mechanistic insights. Food chemistry. 2024 Dec 15;461:140884.
- [3]. Myers JC, et al. Sodium pyrophosphate inhibition of RNA.DNA hybrid degradation by reverse transcriptase. Proceedings of the National Academy of Sciences of the United States of America. 1978 Nov;75(11):5329-33.
- [4]. Choi HJ, et al. Improved bactericidal efficacy and thermostability of Staphylococcus aureus-specific bacteriophage SA3821 by repeated sodium pyrophosphate challenges. Scientific reports. 2021 Nov 25;11(1):22951. [Content Brief]
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