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Cat. No.: HY-177388

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Factor B-IN-6

Factor B-IN-6 is an orally active Factor B inhibitor. Factor B-IN-6 exhibits significant inhibitory activity against activation of the human serum serotonin pathway. Factor B-IN-6 can improve the severity of renal lesions and renal function, and reduce urinary protein in animal models. Factor B-IN-6 is useful for kidney disease research.

For research use only. We do not sell to patients.

CAS No.: 2797066-55-6
Formula: C₂₇H₃₀F₂N₂O₃
Molecular Weight:468.54

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Factor B-IN-6 Chemical Structure

CAS No.: 2797066-55-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Parmacokinetics
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

Factor B-IN-6 (Compound 4B) has obvious inhibitory activity on the activation of human serum bypass pathway, with an IC₅₀ of 40.7 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	T_1/2	CL	AUC_0-last	C_max	F
Mice^[1]	1 mg/kg	i.v.	4.9 mL/min/kg	6.3 h	/	/	/
Mice^[1]	10 mg/kg	p.o.	/	/	6951 ng·h/mL	1637 ng/mL	/
Rat^[1]	1 mg/kg	i.v.	5.7 mL/min/kg	3.5 h	/	/	/
Rat^[1]	5/30 mg/kg	p.o.	/	/	2929* ng·h/mL	361 ng/mL	65 %

In Vivo

Factor B-IN-6 (Compound 4B) (5-60 mg/kg, i.g., twice a day, with an interval of 8 hours, 14 days) reduces the level of urine egg, improves renal function in model of passive Heyman nephritis rats^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Sheep anti-rat Fx1A serum-induced Hyman nephritis rat (7-10 weeks old, weighing 200-300 g) model^[1]
Dosage:

5, 20, 60 mg/kg
Administration:

i.g., twice a day, with an interval of 8 hours, 14 days
Result:

Reduced the level of urine egg, and improved renal function.

Chemical Information

CAS No. 2797066-55-6
Molecular Weight 468.54
Formula C₂₇H₃₀F₂N₂O₃
SMILES

CC1=CC(OC)=C(C2=C1NC=C2)CN(CC[C@H](C3CC(F)(F)C3)C4)[C@@H]4C5=CC=C(C(O)=O)C=C5
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. XinHai Chen, et al. Series of piperidine-substituted benzoic acid compounds, and use thereof. WO2022143940.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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