CDC6 - cell division cycle 6 Gene

Also Known as CDC18L; HsCDC6; MGORS5; HsCDC18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 990

About CDC6

Cytogenetic location: 17q21.2 Genomic coordinates (GRCh38): 17:40,287,879-40,304,657 (from NCBI)

This gene has 7 transcripts (splice variants), 209 orthologues, 1 paralogue and is associated with 3 phenotypes. Broad expression in bone marrow (RPKM 5.8), lymph node (RPKM 4.9) and 20 other tissues.

Summary

The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. This protein functions as a regulator at the early steps of DNA replication. It localizes in cell nucleus during cell cyle G1, but translocates to the cytoplasm at the start of S phase. The subcellular translocation of this protein during cell cyle is regulated through its phosphorylation by Cdks. Transcription of this protein was reported to be regulated in response to mitogenic signals through transcriptional control mechanism involving E2F proteins. [provided by RefSeq, Jul 2008]

CDC6 Products (1)

mRNA	Protein	Name
NM_001254.4	NP_001245.1	cell division control protein 6 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables kinase binding	IPI IPI: Inferred from physical interaction	21041660	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14672932	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of chromosome segregation	IDA IDA: Inferred from direct assay	21041660	GOA
involved in positive regulation of cytokinesis	IMP IMP: Inferred from mutant phenotype	21041660	GOA
involved in regulation of mitotic metaphase/anaphase transition	IMP IMP: Inferred from mutant phenotype	21041660	GOA

Cellular Component GO Annotation	Evidence	References	Source
NOT located in nucleolus	IDA IDA: Inferred from direct assay	21383955	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21041660	GOA
located in spindle midzone	IDA IDA: Inferred from direct assay	21041660	GOA
located in spindle pole	IDA IDA: Inferred from direct assay	21041660	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC6 Protein Structure

AAA_22

Cdc6_C

0
100
200
300
400
500
560 a.a.

Protein Preferred Names	Protein Names
cell division control protein 6 homolog	CDC6 cell division cycle 6 homolog

CDC6 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC6	Q99741	CDK1	Homo sapiens	P06493	Anti Bait CoIP	21041660
Intra	CDC6	Q99741	CDK1	Homo sapiens	P06493	Anti Tag CoIP	21041660
Intra	CDC6	Q99741	CDT1	Homo sapiens	Q9H211	Protein Array	15232106
Intra	CDC6	Q99741	PLK1	Homo sapiens	P53350	Pull Down	21041660
Intra	CDC6	Q99741	PLK1	Homo sapiens	P53350	Protein Kinase Assay	21041660
Intra	CDC6	Q99741	PLK1	Homo sapiens	P53350	Anti Bait CoIP	21041660

Cross: Cross-species interaction Intra: Intraspecies interaction

CDC6 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81295	Phospho-CDC6 (Ser106) Antibody (YA1016)	WB	Human, Rat
HY-P81295A	Phospho-CDC6 (Ser54) Antibody (YA1017)	WB, ICC/IF	Human
HY-P81295B	Phospho-CDC6 (Ser54) Antibody (YA1017)(PBS only)	WB, ICC/IF	Human
HY-P82881	CDC6 Antibody (YA2626)	WB, IHC-P, ICC/IF	Human
HY-P82881A	CDC6 Antibody (YA2626)(PBS only)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Meier-Gorlin Syndrome 5	MGORS5 Meier-Gorlin Syndrome, Type 5
Meier-Gorlin Syndrome 1	Meier-Gorlin Syndrome Ear, Patella, Short Stature Syndrome Microtia, Absent Patellae, Micrognathia Syndrome MGORS1 Eps Ear-Patella-Short Stature Syndrome Ear Patella Short Stature Syndrome Microtia Absent Patellae Micrognathia Syndrome Meier-Gorlin Syndrome, Type 1
Genitourinary Tract Anomalies
Cervical Intraepithelial Neoplasia	CIN
Meier-Gorlin Syndrome 7	MGORS7 Meier-Gorlin Syndrome, Type 7
Cervical Cancer	Cervical Cancer, Somatic Neoplasm Of Uterine Cervix Cervix Cancer Uterine Cervical Neoplasm Cervical Neoplasm Cervix Uteri Cancer Tumor Of The Cervix Uteri CERCA Uterine Cervical Cancer Neoplasms Cervical Uterine Cervical Neoplasms Cervical Cancers Cancer, Cervical, Somatic Malignant Tumor Of Cervix Cervix Carcinoma
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Fanconi Anemia, Complementation Group A	Fanconi Anemia Fanconi Pancytopenia Fanconi Anemia Complementation Group A FANCA Fa Fanconi Panmyelopathy Fanconi'S Anemia Fanconi Anaemia Fanconi'S Anaemia Fanconi Hypoplastic Anemia Estren-Dameshek Variant Of Fanconi Anemia Estren-Dameshek Variant Of Fanconi Pancytopenia Fanconi Anemia Estren-Dameshek Variant Fanconis Anemia
Prostate Cancer	Prostate Carcinoma Prostate Cancer, Familial Prostate Neoplasm Prostate Cancer, Somatic Prostate Cancer, Susceptibility To Prostatic Cancer Prostatic Neoplasms Hereditary Prostate Cancer Prostatic Neoplasm Cancer Of Prostate Carcinoma Of Prostate Familial Prostate Cancer Familial Prostate Carcinoma Malignant Tumor Of Prostate Malignant Neoplasm Of Prostate Prostate Cancer, Familial, Susceptibility To Malignant Tumor Of The Prostate Ngp - New Growth Of Prostate Tumor Of The Prostate Prostate Cancer, Hereditary Cancer Of The Prostate Malignant Neoplasm Of The Prostate Prostatic Carcinoma PC Prca Cancer, Prostate Malignant Prostatic Tumour Malignant Tumour Of Prostate Primary Prostate Cancer Primary Malignant Neoplasm Of Prostate Prostate Gland Cancer
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS02308	CDC6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-11001A	PHA-793887 hydrochloride		/	Unkown
HY-118273	IPS-05002	Inhibitor	/	Unkown
HY-RS19310	Cdc6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25801	Cdc6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDC6	MGD	MGI:1345150
Macaca mulatta	CDC6	VGNC	VGNC:70802
Rattus norvegicus	CDC6	RGD	RGD:1309157
Felis catus	CDC6	VGNC	VGNC:60664
Bos taurus	CDC6	VGNC	VGNC:27081
Canis familiaris	CDC6	VGNC	VGNC:39009
Others	CDC6	NCBI