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Cat. No.: HY-186294

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Methyl-celastrol

Methyl-celastrol is a Celastrol (HY-13067) derivative and triterpenoid compound. Methyl-celastrol exists in Celastrus hypoleucus (Oliv) Warb f argutior Loes and other Celastraceae plants. Methyl-celastrol induces weight loss, reduces body fat, decreases food intake and improves glucose homeostasis. Methyl-celastrol is applicable to obesity-related research.

For research use only. We do not sell to patients.

CAS No.: 1810867-99-2
Formula: C₃₀H₄₀O₄
Molecular Weight:464.64

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Methyl-celastrol Chemical Structure

CAS No.: 1810867-99-2

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
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Biological Activity

Description

In Vitro

Methyl-celastrol (Compound 18) induces weight loss, reduces body fat, decreases food intake, and improves glucose homeostasis in overweight and obese individuals^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1810867-99-2
Molecular Weight 464.64
Formula C₃₀H₄₀O₄
SMILES

C[C@]12[C@@](C([C@@](CC1)3C)=CC=C(C(C)=C4OC)C3=CC4=O)(CC[C@@]5([C@@]2([H])C[C@@](C)(CC5)C(O)=O)C)C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Ralph Mazitschek, et al. Celastrol and derivatives for the treatment of obesity. WO2015148802A1. WIPO (PCT). 2015-03-26.

[2]. Yang H, et al. Targeting tumor proteasome with traditional Chinese medicine. Current drug discovery technologies. 2010 Mar;7(1):46-53. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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