88 Results for "

Ca2++influx

" in MedChemExpress (MCE) Product Catalog:
Products (88)

88 Results for "Ca2++influx" in MCE Product Catalog:

Acetyljujuboside B
Acetyljujuboside B
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Cat. No.: HY-N17738
CAS No.: 194737-13-8
Category:  

Terpenoids Plants Actaea simplex (DC.) Wormsk. ex Fisch. & C. A. Mey. Rhamnaceae Pentacyclic Triterpenoids

Target:  

Calcium Channel

Acetyljujuboside B is a saponin. Acetyljujuboside B can be isolated from seeds of Zizyphus jujuba Mill. var. spinosa. Acetyljujuboside B inhibits Ca 2+ influx. Acetyljujuboside B shows only sustained vasorelaxant effects, with no transient effect on NE-induced vasoconstrictions. Acetyljujuboside B inhibits histamine release from rat peritoneal exudate cells induced by the antigen-antibody reaction [2].
Mavatrep (Standard)
Mavatrep (Standard)
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Cat. No.: HY-16935R
CAS No.: 956274-94-5
Synonyms: JNJ-39439335 (Standard)
Target:  

TRP Channel Reference Standards

Research Areas:  

Neurological Disease

Mavatrep (Standard) is the analytical standard of Mavatrep. This product is intended for research and analytical applications. Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain .
Antiallergic agent-5
Antiallergic agent-5
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Cat. No.: HY-180165
Target:  

Calcium Channel Interleukin Related

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Antiallergic agent-5 (Compound 4f) is an antiallergic agent. Antiallergic agent-5 suppresses Ca 2+ influx. Antiallergic agent-5 suppresses IgE/Ag-induced release of both IL-6 and TNF-α. Antiallergic agent-5 inhibits mast cell degranulation. Antiallergic agent-5 attenuates passive cutaneous anaphylaxis in mice and reduces vascular leakage .
NMDA receptor antagonist-12
NMDA receptor antagonist-12
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Cat. No.: HY-184055
CAS No.: 2643356-08-3
Target:  

iGluR

Research Areas:  

Neurological Disease

NMDA receptor antagonist-12 (Example 17) is an antagonist of NMDA receptors containing the NR2B subunit. NMDA receptor antagonist-12 exerts antagonistic effects on NMDA receptors containing the NR2B subunit and blocks the intracellular Ca 2+ influx mediated by these receptors. NMDA receptor antagonist-12 can be used in research related to diseases such as depression, bipolar disorder, migraine, and pain .
Phenylaminojuglone AJ-2
Phenylaminojuglone AJ-2
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Cat. No.: HY-181755
CAS No.: 109621-29-6
Target:  

NO Synthase

Research Areas:  

Inflammation/Immunology

Phenylaminojuglone AJ-2 is a nitric oxide synthase inhibitor that interacts with soluble guanylate cyclase, β-adrenergic receptor, CaV1.2 calcium channel, KV channel and KCa channel. Phenylaminojuglone AJ-2 blocks extracellular Ca 2+ influx, regulates the activity of the NO?sGC?cGMP signaling pathway, and inhibits pharmacologic and electromechanical contractions of smooth muscle. Phenylaminojuglone AJ-2 is applicable to studies related to intestinal spasm .
NFI23
NFI23
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Cat. No.: HY-182068
Target:  

iGluR

Research Areas:  

Cardiovascular Disease Neurological Disease

NFI23 is a blood-brain barrier-penetrant GluN2B-NMDAR inhibitor, with an IC50 of 1.31 μM and a Ki of 5.98 nM against GluN2B-NMDAR. NFI23 reduces NMDA-induced Ca 2+ influx and ROS production, maintains mitochondrial membrane potential, inhibits neuronal apoptosis, and restores the expression of p-ERK1/2. NFI23 exerts neuroprotective effects against NMDA-induced cytotoxicity and in the rat middle cerebral artery occlusion (MCAO) model. NFI23 can be used for the research of ischemic stroke .
NMDA-IN-1 dihydrochloride
NMDA-IN-1 dihydrochloride
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Cat. No.: HY-12962A
CAS No.: 1784252-90-9
Target:  

iGluR

Research Areas:  

Neurological Disease

NMDA-IN-1 dihydrochloride is a selective NMDA NR2B antagonist with a Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca2+ flux in Ltk- cells expressing the hNR1a/NR2B with a IC50 of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain .
DPO-1 (Standard)
DPO-1 (Standard)
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Cat. No.: HY-100712R
CAS No.: 43077-30-1
Target:  

Potassium Channel Reference Standards Calcium Channel NOD-like Receptor (NLR) Interleukin Related

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

DPO-1 (Standard) is the analytical standard of DPO-1 (HY-100712). This product is intended for research and analytical applications. DPO-1 is a potent Kv1.5 and Kv1.3 (EC50 = 3.1 μM) channels inhibitor with potential immunomodulatory and anti-inflammatory effects. DPO-1 reduces Kv1.3 current density, blunts Ca2+ influx in Ca2+-depleted Jurkat cells, and inhibits IL-2 secretion in activated Jurkat cells. DPO-1 inhibits Uric acid sodium (HY-B2130A) (MSU)-induced NLRP3 inflammasome activation by blocking Kv1.5-mediated K+ efflux. DPO-1 can be used for the study of immunologic disorders and atrial fibrillation [2] .
Assay Types