956274-94-5
956274-94-5
Chemical Structure
Mavatrep
Synonym(s): JNJ-39439335
- CAS No.: 956274-94-5
- Formula:C25H21F3N2O
- Molecular Weight:422.44
IUPAC Name: (E)-2-(2-(2-(4-(trifluoromethyl)styryl)-1H-benzo[d]imidazol-6-yl)phenyl)propan-2-ol
InChIKey: ORDHXXHTBUZRCN-NTEUORMPSA-N
SMILES: OC(C)(C)C1=CC=CC=C1C2=CC=C3N=C(/C=C/C4=CC=C(C(F)(F)F)C=C4)NC3=C2
Biological Activity: Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Mavatrep | 99.67% | Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain. | ||||||||||||||||||||
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Mavatrep (Standard) | ≥98% | Mavatrep (Standard) is the analytical standard of Mavatrep. This product is intended for research and analytical applications. Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain. | ||||||||||||||||||||
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Mavatrep-d6 | Mavatrep-d6 (JNJ-39439335-d6) is a deuterated labeled Mavatrep (HY-16935). Mavatrep (JNJ-39439335) is an orally active, selective and potent TRPV1 antagonist with high affinity for hTRPV1 channels (Ki=6.5 nM). Mavatrep antagonizes capsaicin-induced Ca2+ influx with an IC50 value of 4.6 nM. Mavatrep can be used in some studies of neuropathic pain. | |||||||||||||||||||||
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References
