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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
88 Results for "
Ca2++influx
" in MedChemExpress (MCE) Product Catalog:
Products (88)
88 Results for "Ca2++influx" in MCE Product Catalog:
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PPZ2 is a diacylglycerol (DAG)-activated TRPC3/TRPC6/TRPC7 channel activator with activity in promoting neuronal development and survival. PPZ2 activates recombinant TRPC3/TRPC6/TRPC7 channels in a dose-dependent manner without affecting other TRPC channels. PPZ2 elicits cation currents and calcium ion (Ca(2+)) influx in cultured central neurons. PPZ2 is able to induce BDNF-like neurite outgrowth and neuroprotection, an effect that disappears after TRPC3/TRPC6/TRPC7 knockdown or inhibition. PPZ2 also increases the activation of the calcium-dependent transcription factor cAMP response element binding protein. The effects of PPZ2 suggest that calcium signaling mediated by activation of DAG-activated TRPC channels plays an important role in its neurotrophic effects .
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NMDA-IN-1 is a potent and NR2B-selective NMDA antagonist with Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM; no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor.
Cat. No.: HY-113037AS
CAS No.: 895550-58-0
Synonyms: Farnesyl diphosphate-d6
Cat. No.: HY-N3729
CAS No.: 87402-88-8
Synonyms: Denudatin B
Category:
Cardiovascular Disease Piper betle L. Lignans Piperaceae Phenylpropanoids Plants Disease Research Fields
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Cat. No.: HY-101015
CAS No.: 221632-26-4
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(2E)-OBAA is a potent phospholipase A2 (PLA2) inhibitor, with an IC50 of 70 nM. (2E)-OBAA induces apoptosis of HUVEC cells. (2E)-OBAA blocks Melittin-induced Ca 2+ influx in Trypanosoma brucei, with an IC50 of 0.4 μM [2] .
Cat. No.: HY-N15737
CAS No.: 50982-40-6
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Cat. No.: HY-133168R
CAS No.: 1094250-15-3
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HUP30 is a vasodilating agent. HUP30 stimulates soluble guanylyl cyclase, activate K + channels, and blocks extracellular Ca 2+ influx .
Synonyms: Riparin III
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Riparin is a nonspecific smooth muscle relaxant. Riparin exerts spasmolytic effect by inhibiting Ca 2+ influx and inhibiting the release of intracellular calcium ion stores .
Cat. No.: HY-14656R
CAS No.: 33286-22-5
Synonyms: CRD-401 (Standard)
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Diltiazem (hydrochloride) (Standard) is the analytical standard of Diltiazem (hydrochloride). This product is intended for research and analytical applications. Diltiazem hydrochloride is a Ca 2+ influx inhibitor (slow channel blocker or calcium antagonist).
Cat. No.: HY-14656S1
CAS No.: 1217860-13-3
Cat. No.: HY-14656S2
CAS No.: 1309283-34-8
Synonyms: CRD-401-d6 hydrochloride
Cat. No.: HY-P5796
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Cat. No.: HY-N0081A
CAS No.: 14017-71-1
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Cat. No.: HY-120820
CAS No.: 182633-59-6
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LY320954 is a selective 5-HT2A receptor antagonist, with a Ki of 96 nM. LY320954 potently inhibits Ca 2+ influx in the functional assay (EC50 of 35.5 nM). LY320954 inhibits 5-HT-induced paw swelling in rats, with ED50 of 4.8 mg/kg .
Cat. No.: HY-176021
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U-44069 serinol amide is a derivative of U-44069 (HY-121825). U-44069 serinol amide is a stable analog of the endoperoxide prostaglandin H2 (HY-136500). U-44069 serinol amide is a vasoconstrictor that can induce preglomerular Ca 2+ influx .
Cat. No.: HY-A0057R
CAS No.: 60142-96-3
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Gabapentin (Standard) is the analytical standard of Gabapentin. This product is intended for research and analytical applications. Gabapentin is a potent, orally active P/Q type Ca2+ channel blocker. Gabapentin inhibits neuronal Ca2+ influx and reduction of neurotransmitter release. Gabapentin is a GABA analog that can be used to relieve neuropathic pain [2] .
Cat. No.: HY-W721517
CAS No.: 1126623-20-8
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Cat. No.: HY-169845
CAS No.: 687568-35-0
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Calcium Channel antagonist 6 (Compound 328) is a highly selective antagonist of voltage-gated calcium channel CaV2.2 with an IC50 value of 0.37 μM. Calcium Channel antagonist 6 inhibits of neuron depolarization-induced Ca 2+ influx. Calcium Channel antagonist 6 is promising for research of neuropathic pain .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
