NMDA-IN-1 dihydrochloride
NMDA-IN-1 dihydrochloride is a selective NMDA NR2B antagonist with a Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM. NMDA-IN-1 dihydrochloride inhibits Glu/Gly stimulated Ca2+ flux in Ltk- cells expressing the hNR1a/NR2B with a IC50 of 9.7 nM. NMDA-IN-1 dihydrochloride has no activities on NR2A, NR2C, NR2D, hERG-channel and α1-adrenergic receptor. NMDA-IN-1 dihydrochloride shows excellent activity in the mechanical hyperalgesia assay in rats. NMDA-IN-1 dihydrochloride can be used for the studies of stroke, parkinson, and neuropathic pain.
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- No. CAS: 1784252-90-9
- Fòrmula: C20H24Cl2FN3O
- Peso molecular:412.33
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
| Species | Dose | Route | T1/2 | CL | F |
|---|---|---|---|---|---|
| Dog | 3 mg/kg | p.o. | 390 min | 0.6 mL/min/kg | 87 % |
| Rat | 2 mg/kg | i.v. | 60 min | 12.3 mL/min/kg | / |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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No. CAS 1784252-90-9
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Peso molecular 412.33
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Fòrmula C20H24Cl2FN3O
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SMILES
OC1=CC=C2N=C(CN3CCC(CC4=CC=CC=C4F)CC3)NC2=C1.Cl.Cl
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
NMDA-IN-1 dihydrochloride Related Classifications
HY-12962A Related Classifications
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