2 Results for "

516-72-3

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "516-72-3" in MCE Product Catalog:

5
20(S)-Hydroxycholesterol
20(S)-Hydroxycholesterol
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5 Cited Publications
Cat. No.: HY-12316
CAS No.: 516-72-3
Purity:  99.29%
Synonyms: 20α-Hydroxycholesterol
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Smo Endogenous Metabolite

20(S)-Hydroxycholesterol (20α-Hydroxycholesterol) is an allosteric activator that selectively targets the Smoothened (Smo) of the Hedgehog pathway with an EC50 of ~30 μM (Hedgehog). 20(S)-Hydroxycholesterol binds to the extracellular cysteine-rich domain (CRD) of Smo in a stereoselective manner, activating downstream Gli transcription factors (without inducing transcription of receptor genes in the Wnt pathway). 20(S)-Hydroxycholesterol enhances osteogenic differentiation of bone marrow stromal cells and synergistically activates the Raf/MEK/ERK pathway with Simvastatin (HY-17502) to promote bone regeneration. 20(S)-Hydroxycholesterol can be used to study the mechanisms of developmental biology, oncology, bone, and angiogenesis .
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20(S)-Hydroxycholesterol (Standard)
20(S)-Hydroxycholesterol (Standard)
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Cat. No.: HY-12316R
CAS No.: 516-72-3
Synonyms: 20α-Hydroxycholesterol (Standard)
Category:  

Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

Reference Standards Smo Endogenous Metabolite

20(S)-Hydroxycholesterol (Standard) is the analytical standard of 20(S)-Hydroxycholesterol. This product is intended for research and analytical applications. 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) is an allosteric activator of the oncoprotein smoothened (Smo) that activates the hedgehog (Hh) signaling pathway with an EC50 of 3 μM in a gene transcription reporter assay using NIH3T3 cells .
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