3 Results for "

5853-29-2

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "5853-29-2" in MCE Product Catalog:

2
2 Cited Publications
Cat. No.: HY-N2260
CAS No.: 5853-29-2
Synonyms: (-)-Cephaeline dihydrochloride; NSC 32944
Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM.
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Cat. No.: HY-N2260R
CAS No.: 5853-29-2
Synonyms: (-)-Cephaeline dihydrochloride (Standard); NSC 32944 (Standard)
Cephaeline (dihydrochloride) (Standard) is the analytical standard of Cephaeline (dihydrochloride). This product is intended for research and analytical applications. Cephaeline dihydrochloride is a selective CYP2D6 inhibtor with an IC50 of 121 μM.
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2
2 Cited Publications
Cat. No.: HY-N4118
CAS No.: 483-17-0
Synonyms: (-)-Cephaeline; NSC 32944 free base
Cephaeline ((-)-Cephaeline; NSC 32944) is a ferroptosis inducer, with broad-spectrum anticancer and antiviral activities. Cephaeline induces ferroptosis (Ferroptosis) by upregulating p53, inhibiting NRF2, activating ULK3, downregulating the expressions of SLC7A11 and GPX4 in a p53-dependent manner, reducing GSH and mitochondrial membrane potential, and increasing lipid peroxidation and iron accumulation. Cephaeline inhibits cancer cell proliferation, migration and tumor growth. Cephaeline inhibits Ebola virus (EBOV) VLP entry and infection, with IC50 values of 3.27 μM and 22.18 μM respectively; it also inhibits Zika virus (ZIKV) NS5 RdRp activity (IC50 = 976 nM), and binds to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) RdRp and N protein, with Kd values of 8.9 μM and 53.8 μM respectively. Cephaeline can be used in studies related to breast cancer, lung cancer, COVID-19, EBOV and ZIKV infections .
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