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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
A80426
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "A80426" in MCE Product Catalog:
Cat. No.: HY-120037
CAS No.: 152148-63-5
Target:
5-HT Receptor Adrenergic Receptor Dopamine Receptor TRP Channel NF-κB PI3K Interleukin Related TNF Receptor
Research Areas:
A 80426 is an orally active serotonin (5-HT uptake) inhibitor (IC50 = 13 nM; Ki = 3.8 nM) and α2-Adrenoceptor receptor antagonist (Ki = 2 nM). A 80426 shows weak antagonistic effect to dopamine D1 receptor (Ki = 744 nM) and D2 receptor (Ki = 52 nM). A 80426 upregulates the expression and activity of TRPV1, activates the NF-κB and PI3K pathways, and reduces the levels of pro-inflammatory cytokines IL-1β, IL-6, and TNF-α. A 80426 can be used in research related to inflammatory pain and depression .
Cat. No.: HY-103201
CAS No.: 152148-64-6
Target:
Research Areas:
A 80426 mesylate is an α2-adrenoceptor antagonist. A 80426 mesylate is used in antidepressant research .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
