3 Results for "

APRIL Inhibitors

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "APRIL Inhibitors" in MCE Product Catalog:

Cat. No.: HY-P99568
CAS No.: 2136630-26-5
Synonyms: RC18

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease . The component ratio of this product is Active ingredient : Excipients = 1: 0.5-1: 0.8.
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Cat. No.: HY-P99901
CAS No.: 2382896-07-1
Synonyms: VIS649

Target:  

SARS-CoV

Research Areas:  

Inflammation/Immunology Cancer

Sibeprenlimab (VIS649) is a humanized IgG2 monoclonal antibody which inhibits a proliferation-inducing ligand (APRIL). Sibeprenlimab suppresses pathogenic immunoglobulins (IgA and IgM), while preserving antibody responses to mRNA-based vaccines against SARS-COV-2. Sibeprenlimab reduces urinary protein-to-creatinine ratio (UPCR) and glomerular filtration rate (GFR). Sibeprenlimab is promising for the research of IgA nephropathy (IgAN) .
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Cat. No.: HY-P990706
CAS No.: 2490217-42-8
Synonyms: ALPN-303

Target:  

TNF Receptor

Research Areas:  

Inflammation/Immunology

Povetacicept (ALPN-303) is an engineered Fc fusion protein containing the TACI domain, and acts as a dual APRIL/BAFF antagonist. The Kd value of Povetacicept for human BAFF is 59.3 pM, while its Kd value for human APRIL is 1.00 pM. Povetacicept reduces the activation, proliferation, differentiation and survival of B cells, and inhibits the production of immunoglobulins and autoantibodies. Povetacicept can be used in research related to autoimmune hemolytic anemia, immune thrombocytopenia, systemic lupus erythematosus, lupus nephritis and myasthenia gravis .
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