Telitacicept
Based on 1 Customer Validation
Telitacicept (RC18) is a fully human TACI-Fc fusion protein. Telitacicept is a dual B lymphocyte stimulator (BLyS)/APRIL (a proliferation-inducing ligand) inhibitor that effectively blocks proliferation of B lymphocytes. Telitacicept can be used in research of B-cell autoimmune disease. The component ratio of this product is Active ingredient : Excipients = 1: 0.5-1: 0.8.
For research use only. We do not sell to patients.
- Purity: 99.30%
- CAS No.: 2136630-26-5
- Molecular Weight:75.36 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
(BLyS)/APRIL[1]
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:MOG35-55 peptide-induced EAE mice model (6- to 8-week-old, female)[2]
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Dosage:15mpk and 7.5mpk
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Administration:i.p.
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Result:Reduced the severity of tail paralyses and limb weakness in mice, but not as high efficacy as equal dose of Secukinumab (HY-P9927).
Decreased the number of infiltrating inflammatory cells around the white matter in spinal cord.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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[TNFRSF13B (tumor necrosis factor receptor (TNFR)superfamily member 13B, TACI, transmembrane activator and CAML Interactor)]2-IGHG1 Fc (Fragment constant)
ELISA, FACS, Functional assay
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Immobilized BAFF/TNFSF13B Protein, Human (CHO, HY-P7003) can bind Telitacicept. The EC50 for this effect is 14.06 ng/mL.
Chemical Information
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CAS No. 2136630-26-5
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Appearance Solid
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Molecular Weight 75.36 kDa
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Color White to off-white
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SMILES
[Telitacicept]
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Synonyms
RC18
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)