1 Result for "

BBSKE

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BBSKE" in MCE Product Catalog:

Cat. No.: HY-116749
CAS No.: 217798-39-5
Purity:  ≥98.0%
Synonyms: BBSKE
Target:  

TrxR

Research Areas:  

Cancer

Ethaselen (BBSKE) is an orally active, selective thioredoxin reductase (TrxR) inhibitor with IC50s of 0.5 and 0.35 μM for the wild-type human TrxR1 and rat TrxR1, respectively. Ethaselen specifically binds to the unique selenocysteine-cysteine redox pair in the C-terminal active site of mammalian TrxR1. Ethaselen, an organoselenium compound, is a potent antitumor candidate that exerts potent inhibition on non-small cell lung cancer (NSCLC) by targeting TrxR .
loading...
    loading...