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BION106

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-178728
    BION106

    		PROTACs Parasite Dihydrofolate reductase (DHFR) Infection
    BION106 is a dihydrofolate reductasethymidylate synthase (DHFR-TS) PROTAC degrader. BION106 exhibits extremely strong anti-malarial activity with a Ki and toxicity of 2.68 nM and 0.2 μM against Plasmodium falciparum, and > 100 μM and 44.2 μM in mammalian cells. BION106 can be used for the study of antimalarial parasites (Blue: Idasanutlin ligand (HY-15676); Pink: DHFR-TS ligand (HY-153007); Black: Linker (HY-W021401)) .
    BION106
  • HY-178759
    DHFR-IN-5-amino-PEG3-C2-azido

    		E3 Ligase Ligand-Linker Conjugates Infection
    DHFR-IN-5-amino-PEG3-C2-azido is a synthesized E3 ligase ligand-linker conjugate that can be used to synthesize BION106 (HY-178728). BION106 is a potent DHFR-TS PROTAC degrader with anti-malarial activity .
    DHFR-IN-5-amino-PEG3-C2-azido

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