2 Results for "

BMS986012

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "BMS986012" in MCE Product Catalog:

Cat. No.: HY-P990902
CAS No.: 2733581-82-1
Synonyms: BMS-986012

Research Areas:  

Cancer

Atigotatug (BMS-986012) is a fully human IgG1 antibody binds specifically to FucGM1 with an EC50 of 0.15 nmol/L for FucGM1. Atigotatug is a FcγRIIIa ligand with a Kd of 21 nmol/L. Atigotatug demonstrates antitumor efficacy in multiple mouse small cell lung cancer models .
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Cat. No.: HY-P990902A
CAS No.: 2733581-82-1
Synonyms: BMS-986012 (FUT8-KO)

Target:  

Inhibitory Antibodies

Research Areas:  

Cancer

Atigotatug (FUT8-KO) is an anti-fuc-GM1 monoclonal antibody expressed by CHO cells with the fucosyltransferase 8 gene (FUT8) knocked out, and fucose deficiency enhances the ADCC effect of the antibody. Atigotatug (HY-P990902) is a Fucosyl ganglioside GM1 (fuc-GM1)-targeting IgG1κ type humanized antibody. Atigotatug can induce immune-mediated tumor cell death, such as small cell lung cancer .
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