1 Result for "

BPAM363

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "BPAM363" in MCE Product Catalog:

Cat. No.: HY-178153
CAS No.: 1204572-46-2
Target:  

iGluR

Research Areas:  

Neurological Disease

BPAM363 is an orally active, selective positive allosteric modulator (PAM) of AMPARs with blood-brain barrier penetration. BPAM363 selectively potentiates AMPAR activity in human and rat models, with an EC2x value of 0.96 μM in rat embryonic cortex primary neurons. BPAM363 upregulates BDNF protein expression in rat primary cortical neuronal cultures. BPAM363 enhances AMPA-mediated excitatory postsynaptic responses in rat and mice. BPAM363 can be used for the study of cognitive disorders .
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