2 Results for "

C81S

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "C81S" in MCE Product Catalog:

9
9 Cited Publications
Cat. No.: HY-131328
CAS No.: 2101700-15-4
Purity:  99.88%
Synonyms: LOXO-305
Target:  

Btk

Research Areas:  

Cancer

Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .
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Cat. No.: HY-131328S
Synonyms: LOXO-305-13C,d3
Pirtobrutinib- 13C,d3 (LOXO-305- 13C,d3) is the deuterated, 13C-labeled Pirtobrutinib (HY-131328). Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM .
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