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Cat. No.: HY-131328S

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Pirtobrutinib-¹³C,d₃

(Synonyms: LOXO-305-¹³C,d₃)

Pirtobrutinib-¹³C,d₃ (LOXO-305-¹³C,d₃) is the deuterated, ¹³C-labeled Pirtobrutinib (HY-131328). Pirtobrutinib (LOXO-305), a highly selective and non-covalent next generation BTK inhibitor, inhibits diverse BTK C481 substitution mutations. Pirtobrutinib causes regression of BTK-dependent lymphoma tumors in mouse xenograft models. Pirtobrutinib is also more than 300-fold selective for BTK versus 370 other kinases tested and shows no significant inhibition of non-kinase off-targets at 1 μM.

For research use only. We do not sell to patients.

Formula: C₂₁¹³CH₁₈D₃F₄N₅O₃
Molecular Weight:483.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Pirtobrutinib-¹³C,d₃ Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
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Biological Activity

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Application

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

Unlabeled Cas 2101700-15-4
Molecular Weight 483.44
Formula C₂₁¹³CH₁₈D₃F₄N₅O₃
SMILES

O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)=CC=C3O[13C]([2H])([2H])[2H])=O)C=C2)N
Synonyms

LOXO-305-¹³C,d₃
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gomez E B , et al. Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations[J]. Blood, 2019, 134(Supplement_1):4644-4644.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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Pirtobrutinib-13C,d3

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Pirtobrutinib-13C,d3 Related Classifications

HY-131328S Related Classifications

Pirtobrutinib-¹³C,d₃

Pirtobrutinib-¹³C,d₃ Related Classifications