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Results for "

CARD8

" in MedChemExpress (MCE) Product Catalog:

3

Inhibitors & Agonists

1

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-RS01922
    CARD8 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    CARD8 Human Pre-designed siRNA Set A contains three designed siRNAs for CARD8 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    CARD8 Human Pre-designed siRNA Set A
    CARD8 Human Pre-designed siRNA Set A
  • HY-185207
    CQ80

    		Pyroptosis Infection Cancer
    CQ80 is a PEPD/XPNPEP1 inhibitor and selective CARD8 inflammasome activator. CQ80 has IC50 values of 0.91 μM for PEPD, 43 μM for XPNPEP1. CQ80 promotes the accumulation of Xaa-Pro peptides by inhibiting PEPD and XPNPEP1, releases the fragment of CARD8 for inflammasome formation, and induces pyroptosis via GSDMD cleavage. CQ80 can be used for research on inflammasome, CARD8-expressing cancer cells, HIV-1-infected cell clearance, acute myeloid leukemia (AML) .
    CQ80
  • HY-183739
    CQ31

    		Pyroptosis Caspase Cancer
    CQ31 is a PEPD and XPNPEP1 inhibitor, with an IC50 of 0.67 μM against PEPD and an IC50 of 122 μM against XPNPEP1. CQ31 inhibits the M24B aminopeptidase activity of PEPD and XPNPEP1. CQ31 induces the accumulation of Xaa-Pro-containing peptides, mildly inhibits DPP8/9, and triggers CASP1-dependent pyroptosis via activation of the CARD8 inflammasome and caspase-1. CQ31 can be used in research related to cancers such as acute myeloid leukemia .
    CQ31

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