441022-67-9
Chemical Structure
CQ31
- CAS 番号: 441022-67-9
- Formula:C13H24N2O4
- Molecular Weight:272.34
InChIKey: WJJROQBVMHBPRW-VWYCJHECSA-N
SMILES: CC(C)C[C@@H](N)[C@H](O)C(N1[C@@H](CCC1)C(OC)=O)=O
Biological Activity: CQ31 is a PEPD and XPNPEP1 inhibitor, with an IC50 of 0.67 μM against PEPD and an IC50 of 122 μM against XPNPEP1. CQ31 inhibits the M24B aminopeptidase activity of PEPD and XPNPEP1. CQ31 induces the accumulation of Xaa-Pro-containing peptides, mildly inhibits DPP8/9, and triggers CASP1-dependent pyroptosis via activation of the CARD8 inflammasome and caspase-1. CQ31 can be used in research related to cancers such as acute myeloid leukemia[1][2].
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CQ31 | CQ31 is a PEPD and XPNPEP1 inhibitor, with an IC50 of 0.67 μM against PEPD and an IC50 of 122 μM against XPNPEP1. CQ31 inhibits the M24B aminopeptidase activity of PEPD and XPNPEP1. CQ31 induces the accumulation of Xaa-Pro-containing peptides, mildly inhibits DPP8/9, and triggers CASP1-dependent pyroptosis via activation of the CARD8 inflammasome and caspase-1. CQ31 can be used in research related to cancers such as acute myeloid leukemia. | |||||||||||||||||||||
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Keywords
