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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
2 Results for "
CDK8-IN-2
" in MedChemExpress (MCE) Product Catalog:
Products (2)
2 Results for "CDK8-IN-2" in MCE Product Catalog:
Cat. No.: HY-114178
CAS No.: 1879980-97-8
Target:
Research Areas:
CDK8-IN-2 is an orally active CDK8 inhibitor of an IC50 values of 0.010 μM. CDK8-IN-2 shows a CDK19 IC50 value of 0.026 μM. CDK8-IN-2 inhibits phospho-STAT1, a pharmacodynamic biomarker of CDK8. CDK8-IN-2 inhibits WNT pathway activity. CDK8-IN-2 can be used for the research of colorectal carcinoma .
Cat. No.: HY-184544
CAS No.: 2374703-22-5
Research Areas:
CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC50 values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC50 >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
