2374703-22-5
2374703-22-5
Chemical Structure
CDK8 ligand 2
- CAS. Nr.: 2374703-22-5
- Formula:C30H42N2
- Molecular Weight:430.67
InChIKey: SFCWTQYOYQEKNO-IIDDIWEJSA-N
SMILES: CN(C)[C@H]1CC[C@]2(C)[C@@]3([H])CC[C@]4(C)[C@@H](C5=CC6=C(C=C5)C=CN=C6)CC[C@@]4([H])[C@]3([H])CC[C@@]2([H])C1
Biological Activity: CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC50 values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC50 >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518)[1].
| Art. -Nr. | Produktname | Reinheit | Beschreibung | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
CDK8 ligand 2 | CDK8 ligand 2 is a steroidal CDK8 and CDK19 inhibitor with IC50 values of 16 nM and 8 nM, respectively. CDK8 ligand 2 shows no activity against NEK1 (IC50 >10,000 nM). As a target protein ligand, CDK8 ligand 2 is used for the synthesis of the CDK8 PROTAC degrader (HY-111518). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
Keywords
