1879980-97-8
1879980-97-8
Chemical Structure
CDK8-IN-2
- CAS No.: 1879980-97-8
- Formula:C18H17N5O
- Molecular Weight:319.37
IUPAC Name: N-methyl-3-((1-methyl-1H-indazol-5-yl)methyl)-1H-indazole-5-carboxamide
InChIKey: ZKGWDQMQMQRGLJ-UHFFFAOYSA-N
SMILES: O=C(NC)C=1C=CC=2NN=C(C2C1)CC=3C=CC4=C(C=NN4C)C3
Biological Activity: CDK8-IN-2 is an orally active CDK8 inhibitor of an IC50 values of 0.010 μM. CDK8-IN-2 shows a CDK19 IC50 value of 0.026 μM. CDK8-IN-2 inhibits phospho-STAT1, a pharmacodynamic biomarker of CDK8. CDK8-IN-2 inhibits WNT pathway activity. CDK8-IN-2 can be used for the research of colorectal carcinoma[1].
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CDK8-IN-2 | CDK8-IN-2 is an orally active CDK8 inhibitor of an IC50 values of 0.010 μM. CDK8-IN-2 shows a CDK19 IC50 value of 0.026 μM. CDK8-IN-2 inhibits phospho-STAT1, a pharmacodynamic biomarker of CDK8. CDK8-IN-2 inhibits WNT pathway activity. CDK8-IN-2 can be used for the research of colorectal carcinoma. | |||||||||||||||||||||
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