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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
CFT 8634
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "CFT 8634" in MCE Product Catalog:
1
1 Cited Publications
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Research Areas:
CFT8634 is an orally active BRD9 PROTAC degrader with a DC50 of 0.003 μM (HEK293T.166). CFT8634 recruits the CRBN E3 ubiquitin ligase to form a ternary complex, triggering CRBN-catalyzed BRD9 polyubiquitination and 26S proteasome-mediated degradation. CFT8634 induces sustained tumor regression and inhibits tumor growth in mouse models. CFT8634 can be used in research related to synovial sarcoma, SMARCB-1-deficient cancers, acute myeloid leukemia, malignant rhabdoid tumors, and multiple myeloma .
Cat. No.: HY-169989
CAS No.: 2962967-27-5
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CRBN ligand-11 is the E3 ubiquitin ligase ligand for CFT8634 (HY-145925B). CRBN ligand-11 can be used for the synthesis of PROTACs .
Cat. No.: HY-145925C
CAS No.: 2704617-95-6
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(S,R)-CFT8634 is a BRD9 PROTAC degrader that exerts activity via the ubiquitin-proteasome pathway. (S,R)-CFT8634 can be used in the research of acute myeloid leukemia, malignant rhabdoid tumor, synovial sarcoma, and multiple myeloma .
Cat. No.: HY-169991
CAS No.: 2168258-10-2
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1-(3,3-Difluoro-4-piperidinyl)piperazine is the PROTAC linker of CFT8634 (HY-145925B) and can be used in the synthesis of PROTACs .
Cat. No.: HY-169988
CAS No.: 2633634-64-5
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BRD9 ligand-5 (Compound 172-11) is a PROTAC target protein ligand (Ligands for Target Protein for PROTACs). BRD9 ligand-5 can be utilized for the synthesis of CFT8634 (HY-145925B) .
Cat. No.: HY-169990
CAS No.: 2704621-78-1
Research Areas:
E3 Ligase Ligand-linker Conjugate 142 is a conjugate of E3 ubiquitin ligase ligand + Linker, used for the synthesis of CFT8634 (HY-145925B) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
