3 Results for "

Cardiorythmine

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Cardiorythmine" in MCE Product Catalog:

Ajmaline
Ajmaline
0 Images
Cat. No.: HY-B1167
CAS No.: 4360-12-7
Synonyms: Cardiorythmine; (+)-Ajmaline
Category:  

Cardiovascular Disease Apocynaceae Alkaloids Piperidine Alkaloids Rauvolfia serpentina Plants Disease Research Fields Indole Alkaloids

Target:  

Sodium Channel

Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .
loading...
    loading...
View All Sizes
Ajmaline (Standard)
Ajmaline (Standard)
0 Images
Cat. No.: HY-B1167R
CAS No.: 4360-12-7
Synonyms: Cardiorythmine (Standard); (+)-Ajmaline (Standard)
Category:  

Apocynaceae Alkaloids Piperidine Alkaloids Rauvolfia serpentina Plants Indole Alkaloids

Target:  

Reference Standards Sodium Channel

Ajmaline (Standard) is the analytical standard of Ajmaline. This product is intended for research and analytical applications. Ajmaline (Cardiorythmine) is a sodium channel blocking, class 1A anti-arrhythmic agent. Ajmaline blocks HERG currents with an IC50 of 1 μM in HEK cells and 42.3 μM in Xenopus oocytes. Ajmaline can be used for the research of the ventricular tachyarrhythmia .
loading...
    loading...
View All Sizes
Ajmaline hydrochloride
Ajmaline hydrochloride
0 Images
Cat. No.: HY-B1167A
CAS No.: 4410-48-4
Synonyms: Cardiorythmine hydrochloride; (+)-Ajmaline hydrochloride
Category:  

Apocynaceae Rauvolfia verticillata (Lour.) Baill. Natural Products Plants

Target:  

Others

Ajmaline hydrochloride is a Class Ia antiarrhythmic agent. It inhibits HERG potassium channels with IC50s of 1.0 μmol/l and 42.3 μmol/l in HEK cells and moth spider oocytes respectively. The inhibitory effect of Ajmaline hydrochloride is rapid, reversible, and positive frequency dependent. It acts primarily on the open state of the HERG channel and may also be combined with the inactivated state. The inhibitory effect of ajmaline hydrochloride is dependent on aromatic residues in the S6 domain, and the sensitivity is significantly reduced in the inactivation-deficient HERG S620T channel. It can also slightly affect the activation voltage of HERG channels. Ajmaline hydrochloride's inhibitory effect on HERG channels may contribute to both its potent antiarrhythmic effects and its potential proarrhythmic risk.
loading...
    loading...
View All Sizes
Assay Types