3 Results for "

Cucurbitacin IIa

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Cucurbitacin IIa" in MCE Product Catalog:

1
Cucurbitacin IIa
Cucurbitacin IIa
0 Images
1 Cited Publications
Cat. No.: HY-N1988
CAS No.: 58546-34-2
Synonyms: Hemslecin A
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Disease Research Fields Cancer

Target:  

Survivin Apoptosis EGFR Caspase p38 MAPK Autophagy MEK Raf ERK STAT CaMK

Cucurbitacin IIa (Hemslecin A) is an orally active, blood-brain barrier-permeable EGFR inhibitor with an IC50 of 1.455 nM against human EGFR. Cucurbitacin IIa induces caspase-3-dependent apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton via actin aggregation, arrests the cell cycle at the G2/M phase, and exerts anti-inflammatory activity by inhibiting the EGFR-MAPK signaling pathway. Cucurbitacin IIa can be used in the research of inflammation-related diseases, depression, and cancers such as non-small cell lung cancer .
loading...
    loading...
View All Sizes
Cucurbitacin IIa (Standard)
Cucurbitacin IIa (Standard)
0 Images
Cat. No.: HY-N1988R
CAS No.: 58546-34-2
Synonyms: Hemslecin A (Standard)
Category:  

Triterpenes Terpenoids Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl.

Target:  

Reference Standards Apoptosis EGFR Autophagy MEK Caspase ERK STAT Survivin Raf p38 MAPK CaMK

Cucurbitacin IIa (Hemslecin A) (Standard) is the analytical standard for Cucurbitacin IIa (HY-N1988). This product is used for research and analytical applications. Cucurbitacin IIa is an orally active, blood-brain barrier-penetrating EGFR inhibitor with an IC50 of 1.455 nM for human EGFR. Cucurbitacin IIa induces caspase-3 dependent cell apoptosis, downregulates survivin expression, enhances autophagy levels, disrupts the actin cytoskeleton through actin aggregation, blocks the cell cycle at the G2/M phase, and inhibits the EGFR-MAPK signaling pathway to exert anti-inflammatory activity. Cucurbitacin IIa can be used in research on inflammatory-related diseases, depression, and non-small cell lung cancer and other cancers.
loading...
    loading...
View All Sizes
Cucurbitacin IIa 2-O-β-D-glucoside
Cucurbitacin IIa 2-O-β-D-glucoside
0 Images
Cat. No.: HY-N12552
CAS No.: 77704-34-8
Synonyms: Hemslecin A 2-O-β-d-glucopyranoside
Category:  

Cucurbitaceae Plants Hemsleya chinensis Cogn. ex Forbes et Hemsl. Saccharides Monosaccharides

Target:  

Others

Cucurbitacin IIa 2-O-β-D-glucoside is a glycoside cucurbitacin isolated from the genus Hemsleya (Cucurbitaceae). Extracts of Hemsleya have the potential to be used in research on bronchitis, bacillary dysentery, and tuberculosis .
loading...
    loading...
View All Sizes
Assay Types