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DMS53-CR

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1 Results for "DMS53-CR" in MCE Product Catalog:

Guanosine triphosphate
Guanosine triphosphate
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Cat. No.: HY-113225
CAS No.: 86-01-1
Synonyms: GTP
Category:  

Infection Human Gut Microbiota Metabolites Natural Products Microorganisms Endogenous metabolite Disease Research Fields Cancer

Target:  

Endogenous Metabolite DNA/RNA Synthesis Apoptosis Mitosis

Guanosine triphosphate (GTP) is a critical nucleotide and regulator of cellular metabolism. Guanosine triphosphate promotes ribosomal DNA localization, pre-rRNA transcription and ribosome biogenesis by binding to RNA polymerase I and GPN proteins (GPN1/3). Guanosine triphosphate links MYC-dependent ribosome biogenesis to nucleotide sufficiency, acts as a metabolic gatekeeper supporting protein synthesis, DNA/RNA synthesis and cellular signal transduction, while also participating in the physiological activities of pancreatic β-cells and serving as an oxidative substrate for reactive oxygen species. In small cell lung cancer with high MYC expression, Guanosine triphosphate accumulates through the IMPDH-driven synthetic pathway, thereby affecting apoptosis and mitotic processes. Guanosine triphosphate is used in the research of small cell lung cancer, hepatoblastoma and cellular metabolism .
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