Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
3 Results for "
E166A
" in MedChemExpress (MCE) Product Catalog:
Products (3)
3 Results for "E166A" in MCE Product Catalog:
Cat. No.: HY-170598
CAS No.: 3119106-17-8
Target:
Research Areas:
HP211206 is a bifunctional CRBN-recruiting SARS-CoV-2 M pro PROTAC degrader with a CRBN IC50 of 3.2 μM and a SARS-CoV-2 M pro DC50 of 621 nM. HP211206 recruits E3 ubiquitin ligase CRBN to drive ubiquitination and proteasomal degradation of wild-type SARS-CoV-2 M pro and E166 mutant while inhibiting M pro enzymatic activity, exhibits no cytotoxicity against normal mammalian cells at tested concentrations, and can be used for the study of COVID-19 and SARS-CoV-2 infection
Cat. No.: HY-179102
CAS No.: 2648754-84-9
Target:
Research Areas:
SARS-CoV-2 Mpro-IN-51 (compound 4) is a SARS-CoV-2 Mpro inhibitor (IC50 = 26 nM). SARS-CoV-2 Mpro-IN-51 has inhibitory effects on the triple mutant L50F/E166A/L167F. SARS-CoV-2 Mpro-IN-51 can be used for research on viral infections .
Cat. No.: HY-181263
Target:
Research Areas:
Jun13698 is a SARS-CoV-2 main protease (M pro) inhibitor with Ki values of 65.6 nM, 510.0 nM, and 117.5 nM against the wild-type, E166V, and E166A mutants, respectively. Jun13698 forms stable complexes with wild-type and mutant M pro to mediate enzyme inhibition. Jun13698 exhibits antiviral activity against SARS-CoV-2 variants carrying the E166V/A mutation. Jun13698 is applicable to COVID-19-related research .
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
