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Cat. No.: HY-179102

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SARS-CoV-2 Mpro-IN-51

SARS-CoV-2 Mpro-IN-51 (compound 4) is a SARS-CoV-2 Mpro inhibitor (IC₅₀ = 26 nM). SARS-CoV-2 Mpro-IN-51 has inhibitory effects on the triple mutant L50F/E166A/L167F. SARS-CoV-2 Mpro-IN-51 can be used for research on viral infections.

For research use only. We do not sell to patients.

CAS No.: 2648754-84-9
Formula: C₂₃H₂₉N₄NaO₈S
Molecular Weight:544.55

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (269 KB)

SARS-CoV-2 Mpro-IN-51 Chemical Structure

CAS No.: 2648754-84-9

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
Vero C1008	CC₅₀	>200 μM Compound: 2e	Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo luminescent cell viability assay Cytotoxicity against African green monkey Vero E6 cells assessed as reduction in cell viability after 24 hrs by CellTiter-Glo luminescent cell viability assay	[PMID: 34118724]

Chemical Information

CAS No. 2648754-84-9
Molecular Weight 544.55
Formula C₂₃H₂₉N₄NaO₈S
SMILES

[H]C([C@@H](NC([C@@H](NC(C1=CC2=C(N1)C=CC=C2OC)=O)CC3CC3)=O)C[C@@H]4CCNC4=O)(S(=O)(O[Na])=O)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Fischer C, et al. Structural insights into the nirmatrelvir-resistant SARS-CoV-2 Mpro L50F/E166A/L167F triple mutant-inhibitor-complex reveal strategies for next generation coronaviral inhibitor design. RSC Med Chem. 2025 Aug 15;16(10):5032-5040. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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