2 Results for "

E430G

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "E430G" in MCE Product Catalog:

Cat. No.: HY-P99470
CAS No.: 2109730-69-8
Synonyms: GEN1029

Target:  

TNF Receptor Apoptosis

Research Areas:  

Cancer

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects .
loading...
    loading...
Cat. No.: HY-P99674
CAS No.: 2364496-42-2
Synonyms: GEN-3009

Research Areas:  

Cancer

Ivicentamab (GEN-3009) is a bispecific antibody targeting CD37 with dual epitopes. Ivicentamab carries an E430G mutation in the Fc region, which efficiently promotes IgG hexamer formation on the surface of target cells. Ivicentamab provides the parental variable regions for an H429F-engineered anti-CD37 bispecific antibody, enabling it to exert complement-dependent cytotoxicity in Daudi lymphoma cells. Ivicentamab is mainly used in lymphoma-related research .
loading...
    loading...