2. Apoptosis
  3. TNF Receptor Apoptosis
  4. Benufutamab

Benufutamab  (Synonyms: GEN1029)

Cat. No.: HY-P99470 Purity: 98.62%
COA

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Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects.

For research use only. We do not sell to patients.

Benufutamab Chemical Structure

Benufutamab Chemical Structure

CAS No. : 2109730-69-8

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Benufutamab Related Antibodies

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Description

Benufutamab (GEN1029) is a death receptor 5 (DR5)-specific agonistic antibody. Benufutamab is a mixture of 2 noncompeting DR5-specific IgG1 antibodies, each with an E430G mutation in the Fc domain. Benufutamab has antitumor effects[1].

In Vitro

Benufutamab (GEN1029; HexaBody-DR5/DR5; 20 µg/mL; 24 hours) induces potent cytotoxicity in multiple myeloma (MM) cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Benufutamab Related Antibodies

Cell Viability Assay[1]

Cell Line: Multiple myeloma (MM) cells
Concentration: 20 µg/mL
Incubation Time: 24 hours
Result: Induced potent cytotoxicity.
In Vivo

Benufutamab (GEN1029; HexaBody-DR5/DR5; 0.5-2 mg/kg; i.p.; once a week; for 9 weeks) shows significant antitumor activity in PDX models for colorectal cancer[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Balb/c athymic nude or NU/NU nude mice injected with colorectal cancer (CRC) cells[2]
Dosage: 0.5 mg/kg, or 2 mg/kg
Administration: i.p.; once a week; for 9 weeks
Result: Showed significant antitumor activity.
Clinical Trial
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Benufutamab]
Shipping

Shipping with dry ice.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 98.62%

COA (231 KB)

Handling Instructions (2659 KB)
References
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Benufutamab Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Benufutamab2109730-69-8GEN1029GEN 1029GEN-1029TNF ReceptorApoptosisTumor Necrosis Factor ReceptorTNFRDR5E430Gantitumor effectsInhibitorinhibitorinhibit

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