1 Result for "

EOS215

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "EOS215" in MCE Product Catalog:

Cat. No.: HY-P991621
Synonyms: EOS-215

Target:  

TREM receptor

Research Areas:  

Cancer

EOS006215 (EOS-215) is a humanized monoclonal antibody targeting TREM-2. EOS006215 competes with TREM2 ligands, prevents TREM2 multimerization, and blocks downstream signaling. EOS006215 inhibits efferocytosis, reprograms transcriptomic profiles of monocyte-derived macrophages, alters metabolism and immune response genes, and increases pro-inflammatory marker secretion. EOS006215 reduces metastasis burden, delays tumor growth, and reprograms the tumor microenvironment to overcome anti-PD-1 resistance. EOS006215 can be used for the research of triple negative breast cancer and colorectal cancer .
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