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ERB 2

" in MedChemExpress (MCE) Product Catalog:
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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-180850
    ERB-2

    		PROTACs Estrogen Receptor/ERR Reactive Oxygen Species (ROS) Apoptosis Cancer
    ERB-2 is a selective ERβ PROTAC degrader. ERB-2 removes the inhibitory effect of ERβ on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer .
    ERB-2
  • HY-180851
    ER ligand-14

    		Estrogen Receptor/ERR Cancer
    ER ligand-14 is an estrogen receptor (ER) ligand. ER ligand-14 can serve as a ligand for target protein for PROTAC, and can be used to develop and design degradative agents for PROTAC ERβ, such as ERB-2 (HY-180850). ERB-2 displays favorable antiproliferative activity against Osimertinib (HY-15772) resistance NSCLC cells .
    ER ligand-14
  • HY-180852
    ER ligand-14-PEG3-Boc

    		Target Protein Ligand-Linker Conjugates Estrogen Receptor/ERR Cancer
    ER ligand-14-PEG3-Boc is a conjugate of a target protein ligand and linker, composed of an estrogen receptor ligand and a corresponding linker. ER ligand-14-PEG3-Boc can be used to synthesize PROTACs such as ERB-2 (HY-180850). ERB-2 exhibits good antiproliferative activity against Osimertinib (HY-15772)-resistant non-small cell lung cancer .
    ER ligand-14-PEG3-Boc

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