ERB-2
ERB-2 is a selective ERβ PROTAC degrader. ERB-2 removes the inhibitory effect of ERβ on ROS, leading to the accumulation of ROS, mitochondrial damage, and ultimately triggering cell apoptosis (apoptosis). ERB-2 significantly inhibits tumor growth in the nude mouse model of NCI-H1975OR tumors. ERB-2 can be used for the study of non-small cell lung cancer.
(Pink: Estrogen Receptor/ERR ligand (HY-180851); Blue: VHL ligand (HY-112078); Black: linker (HY-141209)).
For research use only. We do not sell to patients.
- Formula: C46H55N5O11S
- Molecular Weight:886.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All PROTACs Isoforms
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Biological Activity
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ERβ |
VHL |
Chemical Information
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Molecular Weight 886.02
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Formula C46H55N5O11S
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SMILES
O=C([C@H]1N(C([C@H](C(C)(C)C)NC(COCCOCCOCCOC2=CC(C3=NC4=CC(O)=CC(C=C)=C4O3)=CC=C2O)=O)=O)C[C@H](O)C1)N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ERB-2 Related Classifications
HY-180850 Related Classifications
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