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ERM proteins

" in MedChemExpress (MCE) Product Catalog:

2

Inhibitors & Agonists

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Biochemical Assay Reagents

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Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-E70182
    Hyaluronidase 2

    EC:3.2.1.35; HYAL2

    		 CD44 Cardiovascular Disease Inflammation/Immunology Cancer
    Hyaluronidase 2 (EC:3.2.1.35; HYAL2) is a hyaluronidase. Hyaluronidase 2 cleaves high-molecular-weight hyaluronan into intermediate, ~20 kDa, and tetrasaccharide fragments. Hyaluronidase 2 directly interacts with CD44 and ERM proteins, reduces CD44 hyaluronan binding capacity and ERM activation. Hyaluronidase 2 can be used for the research of gliomas, inflammatory bowel disease, congenital heart defects, heart failure .
    Hyaluronidase 2
  • HY-181107
    DNA Gyrase/ribosomes-IN-1

    		Bacterial DNA/RNA Synthesis Cytochrome P450 Infection
    DNA Gyrase/ribosomes-IN-1 is a bacterial ribosome and DNA gyrase inhibitor, with IC50 values of 1.11 μM and 3.31 μM, respectively. DNA Gyrase/ribosomes-IN-1 also inhibits CYP3A4, with an IC50 of 18.5 μM, and exhibits stability in mouse plasma and liver microsomes. DNA Gyrase/ribosomes-IN-1 inhibits bacterial protein synthesis by interacting with ribosomal RNA and associated sites. DNA Gyrase/ribosomes-IN-1 suppresses bacterial DNA replication by interacting with the gyrase complex. DNA Gyrase/ribosomes-IN-1 restores activity against macrolide-resistant, erm-mediated Gram-positive pathogens and enhances activity against Gram-negative bacteria such as Haemophilus influenzae and Moraxella catarrhalis. DNA Gyrase/ribosomes-IN-1 can be used in research on community-acquired bacterial pneumonia .
    DNA Gyrase/ribosomes-IN-1

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