1 Result for "

ES-8891

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "ES-8891" in MCE Product Catalog:

Cat. No.: HY-117913
CAS No.: 129445-88-1
Target:  

Renin

Research Areas:  

Cardiovascular Disease

ES-8891 is a renin inhibitor. Oral administration of ES-8891 to normotensive sodium-depleted macaques for one week significantly reduced plasma renin activity, immunoreactive renin concentrations, and plasma angiotensin I concentrations, while mean blood pressure decreased significantly, without significant changes in heart rate. ES-8891 regulates blood pressure by inhibiting plasma renin levels and renal renin synthesis .
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