Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
Fe-S cluster
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "Fe-S cluster" in MCE Product Catalog:
130
Research Areas:
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research .
1
1 Cited Publications
Target:
Research Areas:
Cisd2 agonist 2 (compound 6) is a Cisd2 activator (EC50=191 nM), and Cisd2 levels are associated with non-alcoholic fatty liver disease (NAFLD). Cisd2 agonist 2 has no significant in vivo toxicity in Cisd2hKO-het mice (heterozygous hepatocyte-specific Cisd2 knockout). Cisd2 (CDGSH iron sulfur domain 2) is a zinc finger protein that is mainly localized in the endoplasmic reticulum or mitochondrial membrane. Cisd2 participates in mitochondrial function by forming homodimers containing two redox-active 2Fe-2S clusters .
Cat. No.: HY-W698249
CAS No.: 299-29-6
Target:
Research Areas:
Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe 2+ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to *E. coli* infection and iron deficiency anemia .
Cat. No.: HY-12040S
Synonyms: STA-4783-d2
Cat. No.: HY-W698249R
CAS No.: 299-29-6
Target:
Ferrous gluconate (Standard) is the analytical standard of Ferrous gluconate. This product is intended for research and analytical applications. Ferrous gluconate is a highly water-soluble iron-containing agent with high bioavailability and bactericidal activity. As a non-heme iron, Ferrous gluconate is used for meat product fortification and improvement of iron deficiency anemia. Ferrous gluconate induces ferroptosis in E. coli through Fe 2+ infiltration, reactive oxygen species burst, lipid peroxidation and direct interaction with DNA. Ferrous gluconate also downregulates the SOS responsive transcriptional repressor LexA. In addition, Ferrous gluconate regulates multiple key pathways in E. coli such as fatty acid metabolism, iron-sulfur cluster assembly and pyruvate metabolism, and is applied in studies related to *E. coli* infection and iron deficiency anemia .
Cat. No.: HY-E71602
Target:
Research Areas:
2-Oxoacid oxidoreductase (ferredoxin) (EC 1.2.7.11) contains thiamine diphosphate and [4Fe-4S] clusters.
Cat. No.: HY-E71610
Target:
Research Areas:
2-Oxoglutarate synthase (EC 1.2.7.3) contains thiamine diphosphate and two [4Fe-4S] clusters.
Cat. No.: HY-E71575
Target:
Research Areas:
2-Iminoacetate synthase (EC 4.1.99.19) binds a [4Fe-4S] cluster that is coordinated by 3 cysteines and an exchangeable S-adenosyl-L-methionine molecule.
Cat. No.: HY-E71221
Target:
Research Areas:
α-D-Ribose 1-methylphosphonate 5-phosphate C-P-lyase (EC 4.7.1.1) can be isolated from Escherichia coli and involves the [4Fe-4S] cluster and S-adenosyl-L-methionine (SAM) radical.
Cat. No.: HY-E71453U
Target:
Research Areas:
23S rRNA (uracil1939-C5)-Methyltransferase (EC 2.1.1.190) specifically methylates uracil1939 at C5 in 23S rRNA. 23S rRNA (uracil1939-C5)-Methyltransferase (EC 2.1.1.190) contains an [4Fe-4S] cluster coordinated by four conserved cysteine residues.
Cat. No.: HY-E71453C
Target:
Research Areas:
23S rRNA (adenine2503-C2)-methyltransferase (EC 2.1.1.192) contains a [4Fe-4S] cluster and belongs to the "radical AdoMet" (radical SAM) family. It employs a radical-based mechanism to methylate the adenosine residue using a CH? group derived from S-adenosyl-L-methionine, while retaining the hydrogen atom at the C-2 position of adenosine 2503 in the 23S rRNA.
- 1
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
