1 Result for "

GC1118

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "GC1118" in MCE Product Catalog:

Cat. No.: HY-P991571
Synonyms: GC-1118A

Target:  

EGFR PERK Akt

Research Areas:  

Cancer

GC1118 (GC-1118A) is a fully human anti-EGFR monoclonal antibody with binding affinity of 0.16 nM (KD) to EGFR. GC1118 displays potent inhibitory effects on high- and low-affinity EGFR ligand-induced signaling. GC1118 shows potent anti proliferative activity in KRAS wild-type and KRAS mutant cells. GC1118 can reach the tumor by crossing both BBB (blood-brain barrier) and BTB (brain-tumor barrier) and shows superior anti-tumor effects in various mice xenograft models. GC1118 can be used for the researches of cancer, such as colorectal cancer .
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