7 Results for "

GDF11

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "GDF11" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-P99720
CAS No.: 1373715-00-4
Synonyms: ACE-536; luspatercept–aamt

Target:  

TGF-beta/Smad

Research Areas:  

Cardiovascular Disease

Luspatercept (ACE-536) is a recombinant modified ActRIIB fusion protein that binds with transforming growth factor β superfamily ligands. Luspatercept increases the erythrocyte numbers and promotes maturation of erythroid precursors. Luspatercept binds with GDF11 and inhibits Smad2/3 signaling. Luspatercept can be used for the research of anemia .
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1
1 Cited Publications
Cat. No.: HY-P99590A
Synonyms: RAP-011
Sotatercept (mIgG2a) (RAP-011), the murine homolog of Sotatercept (ACE-011) (HY-P99590), is a soluble activin receptor type IIA (ActRIIA) ligand trap. Sotatercept (mIgG2a) inhibits the binding of activin A and other members of the TGF-β superfamily (such as Activin A/B, GDF11 and BMP9/10) to their receptors by combining and neutralizing them, thereby regulating cell proliferation and differentiation. Sotatercept (mIgG2a) mainly inhibits the SMAD2/3 signaling pathway, and can be used in various diseases such as chronic kidney disease. Sotatercept (mIgG2a) reduces the expression of erythropoietic hepcidin (ERFE), regulates iron metabolism, and promotes red blood cell production. Sotatercept (mIgG2a) has a dual effect of promoting bone formation (anabolic) and inhibiting bone resorption (catabolic) .
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Cat. No.: HY-RS05351
Research Areas:  

Others

GDF11 Human Pre-designed siRNA Set A contains three designed siRNAs for GDF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS18279
Research Areas:  

Others

Gdf11 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gdf11 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS24757
Research Areas:  

Others

Gdf11 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gdf11 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P700020AF
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDF11; Growth/Differentiation Factor 11; Growth Differentiation Factor 11; Bone Morphogenetic Protein 11; BMP-11; GDF-11; BMP11; VHO
Species:  
Source:  
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Cat. No.: HY-P70222Y
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GDF11; Growth/Differentiation Factor 11; Growth Differentiation Factor 11; Bone Morphogenetic Protein 11; BMP-11; GDF-11; BMP11; VHO
Species:  
Source:  
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