1 Result for "

GLT-1 expression upregulator

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "GLT-1 expression upregulator" in MCE Product Catalog:

Cat. No.: HY-182601
CAS No.: 1639784-02-3
Research Areas:  

Neurological Disease

MC-100093 is an orally active, blood-brain barrier-permeable GLT-1 expression upregulator . MC-100093 upregulates the expression of GLT-1 and xCT in rats, and alleviates sedative agent-induced GLT-1 downregulation, IL-6 upregulation and motor hyperactivity. MC-100093 upregulates GLT-1 expression and enhances glutamate uptake in astrocyte-neuron co-culture systems. MC-100093 reduces ethanol consumption and preference, and exerts gender-specific antidepressant-like effects . MC-100093 can be used in studies related to sedative agent overdose, mood disorders and alcohol use disorders .
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