1 Result for "

Gen1047

" in MedChemExpress (MCE) Product Catalog:
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1 Results for "Gen1047" in MCE Product Catalog:

Cat. No.: HY-P990953
CAS No.: 2640279-10-1
Synonyms: Gen1047

Target:  

CD3

Research Areas:  

Cancer

Zubotamig (Gen1047) is an CD3E/VTCN1-targeting Ig(G1 -κ_G1 -λ2) type chimeric human antibody. The recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001). Zubotamig induces T-cell mediated cytotoxicity of B7H4-positive tumor cells, triggers T-cell activation, and induces cytokine release from T cells in the presence of B7H4-expressing tumor cells. Zubotamig demonstrates antitumor activity in mouse patient-derived xenograft (PDX) models. Zubotamig can be used for the research of solid cancers (including breast, ovarian and lung cancer) .
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