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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
HL8
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "HL8" in MCE Product Catalog:
HL-8 is a PI3Kα PROTAC degrader. HL-8 promotes the ubiquitination and degradation of PI3Kα. HL-8 reduces pAKT levels. HL-8 has anticancer activity against colon and cervical cancer (Pink: PI3Kα ligand (HY-143277); Blue: E3 ligase VHL ligand (HY-138678); Black: linker (HY-W002042)) .
Cat. No.: HY-W002042
CAS No.: 929-17-9
Target:
Research Areas:
7-Aminoheptanoic acid is a PROTAC linker. 7-Aminoheptanoic acid can be used to synthesize PROTAC molecules (e.g. HL-8 (HY-143275)).
Cat. No.: HY-143277
CAS No.: 2766352-49-0
Research Areas:
HL-2 is a ligand of the target protein PI3K kinase of HL-8 (HY-143275), which can be used for PROTAC synthesis .
Cat. No.: HY-143276A
Purity: 97.20%
Research Areas:
(S,S,R)-AHPC-C6-NH2 hydrochloride is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275) .
Cat. No.: HY-143276
CAS No.: 2411422-68-7
Research Areas:
(S,S,R)-AHPC-C6-NH2 is the E3 ligase ligand-linker conjugate, which can be utilized for synthesis of PROTAC HL-8 (HY-143275) .
Cat. No.: HY-143897
CAS No.: 2762767-56-4
PIM1-IN-3 (Compound HL8) is a potent inhibitor of PIM1. PIM1-IN-3 shows selective inhibition for the PIM-1 enzyme. PIM1-IN-3 induces apoptosis efficiently in Colo320 cells. PIM1-IN-3 has the potential for the research of cancer diseases .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
