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Headpiece

" in MedChemExpress (MCE) Product Catalog:

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Inhibitors & Agonists

1

Biochemical Assay Reagents

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W002805
    2-Bromoisonicotinic acid
    1 Publications Verification

    		 Drug Intermediate Others
    2-Bromoisonicotinic acid is a (hetero)aryl bromide building block and DNA-conjugated headpiece for photochemical C-H heteroarylation in DNA-encoded library synthesis. 2-Bromoisonicotinic acid generates a nucleophilic pyridyl radical intermediate. 2-Bromoisonicotinic acid, when conjugated to DNA, leaves electrophilic handles intact for subsequent library diversification .
    2-Bromoisonicotinic acid
  • HY-185464
    DBCO-Headpiece

    		Drug Derivative Others
    DBCO-Headpiece is a conjugate of DBCO-PEG4-NHS ester (HY-140272) and Headpiece (HY-185129).
    DBCO-Headpiece
  • HY-185129
    Headpiece

    		Biochemical Assay Reagents Others
    Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.
    Headpiece

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