Headpiece 

Headpiece is a short, covalently linked double-stranded DNA (dsDNA). It is designed as the starting point of DNA-Encoded Libraries (DELs) synthesis. In each chemical synthesis step, the compounds are encoded by enzymatically ligating the respective DNA tags to the Headpiece. Finally, a closing primer containing the distal primer-binding site for PCR amplification is added to complete the library synthesis/encoding.

4937.20

C₁₅₄H₂₁₅N₅₂O₁₀₁P₁₇

NCCCCC(COP(O)(OCCOCCOCCOP(O)(O[C@@H]1C[C@H](N2C(N=CN=C3N)=C3N=C2)O[C@@H]1COP(O)(O[C@@H]4C[C@H](N5C(N=C(N)C=C5)=O)O[C@@H]4COP(O)(O[C@@H]6C[C@H](N7C(NC(C(C)=C7)=O)=O)O[C@@H]6COP(O)(O[C@@H]8C[C@H](N9C(N=C(N)NC%10=O)=C%10N=C9)O[C@@H]8COP(O)(O[C@@H]%11C[C@H](N%12C(N=CN=C%13N)=C%13N=C%12)O[C@@H]%11COP(O)(O[C@@H]%14C[C@H](N%15C(N=C(N)NC%16=O)=C%16N=C%15)O[C@@H]%14COP(O)(O)=O)=O)=O)=O)=O)=O)=O)=O)COP(O)(OCCOCCOCCOP(OC[C@@H]%17C(OP(O)(OC[C@@H]%18[C@H](OP(O)(OC[C@@H]%19[C@H](OP(O)(OC[C@@H]%20[C@H](OP(O)(OC[C@@H]%21[C@H](OP(O)(OC[C@@H]%22[C@H](OP(O)(OC[C@@H]%23[C@H](OP(O)(OC[C@@H]%24[C@H](O)C[C@H](N%25C(N=C(N)C=C%25)=O)O%24)=O)C[C@H](N%26C(N=C(N)C=C%26)=O)O%23)=O)C[C@H](N%27C(N=C(N)C=C%27)=O)O%22)=O)C[C@H](N%28C(NC(C(C)=C%28)=O)=O)O%21)=O)C[C@H](N%29C(N=C(N)C=C%29)=O)O%20)=O)C[C@H](N%30C(N=CN=C%31N)=C%31N=C%30)O%19)=O)C[C@H](N%32C(N=C(N)NC%33=O)=C%33N=C%32)O%18)=O)C[C@H](N%34C(NC(C(C)=C%34)=O)=O)O%17)(O)=O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Clark MA, Acharya RA, Arico-Muendel CC, et al. Design, synthesis and selection of DNA-encoded small-molecule libraries. Nat Chem Biol. 2009;5(9):647-654.  [Content Brief]